How Long does Hydroxychloroquine Stay in your System?

Hydroxychloroquine is known for its long half-life, meaning it remains in the body much longer than many other medications. On average, it has a half-life of 40–50 days, and it may take up to 6 months for the drug to be completely eliminated after the final dose.

This happens because hydroxychloroquine is stored in body tissues such as the liver, lungs, and skin, even after blood levels begin to drop. For many patients with autoimmune conditions, this long duration helps maintain consistent therapeutic effects.

In routine treatment, Hydroxychloroquine 200mg is commonly prescribed as a standard dose for long-term management under medical supervision.